Endocrine Abstracts

Introduction: Hyperandrogenaemia in adolescence is associated with hirsutism, acne and menstrual irregularity and is considered as an important risk for polycystic ovary syndrome and subsequent risk of cardiovascular disease and type 2 diabetes. The aim of this study was to establish if self-reported oligo/amenorrhea were associated with hyperandrogenemia and metabolic disturbances in adolescence.Subjects and methods: A cross sectional study using postal...

Low birth weight infants have higher mortality rates and are at a greater risk of impaired immunity in later life than are their normal-birth-weight counterparts. The aim was to investigate the effect of maternal dietary fat supplementation during the first or second half of gestation on the plasma immunoglobulin A concentration in her offspring.Six pregnant sows were randomly allocated to receive 10% extra energy derived from dietary fat during either t...

Introduction: Pregnancy is a stress test on maternal thyroid and pregnant women may be more susceptible to thyroid dysfunction. Consequences of this may be harmful for the mother and fetus. Smoking has been associated with alterations in thyroid hormone concentrations, but little knowledge exists on this association in pregnant women.Subjects and methods: The study population is large, prospective population-based Northern Finland Birth Cohort 1986 (n...

Epidemiological studies have suggested that in man low birth weight followed by rapid catch-up growth dramatically increase the risk of adulthood diabetes and metabolic syndrome. This experiment investigated the effect of a high fat, high cholesterol post-weaning diet on blood glucose levels of low (L) and normal (N) birth weight pigs.Low (L: <10thpercentile; n=6) and normal (N: 40th - 60th percentile; n=12) birth weig...